Stabilization of drug nanocrystals using fibroin Skała

Stabilization of drug nanocrystals using fibroin Rani Dhole Wymiary: 22,9 x 15,2 Oprawa: Miękka Liczba stron: 112 Data wydania: 20.03.2020 Wydawnictwo: LAP Lambert Academic Publishing ISBN: 9786202515092 Nanocrystals of the poorly water-soluble drugs is a promising strategy. To stabilize the drug nanocrystals stabilizers are usually used; however the use of common stabilizers is limited by weak stabilization effect and toxicological concerns for long-term treatment. The present work was aimed to investigate the potential of natural silk protein as novel stabilizer for nanocrystal of hydrochlorothiazide which was a model drug. The nanocrystals of drug with hydrophobic protein stabilizer were prepared by antisolvent precipitation method.Prepared nanocrystals were evaluated for parameters like particle size zeta potential DSC XRD %crystallinity SEM drug content and in vitro dissolution test. Stabilization efficiency of nanocrystals was assessed by their % crystallinity for 3 months. Optimized batch R2 has shown smaller particle size highest drug content and drug dissolution. Nanocrystals has shown the extended release due to coat of fibroin around the hydrochlorothiazide. From the % crystallinity study it was found that there was not significant change in the nanocrystals prepared using fibroin. So it was concluded that the fibroin is good stabilizer for drug nanocrystals.